What is Diabetes Mellitus

A disease characterized by a complete or partial inability of the body to burn sugar as a fuel. It occurs in all age groups, most diabetics are obese, or slightly obese, middle-aged women.

The tendency to diabetes may be inherited and in such cases the disease may be brought on by obesity, infection, emotional shock, surgery, pregnancy, or the onset of change-of-life. Diabetic women often bear abnormally large children some years before they develop the disease.

What Causes Diabetes?

Improper functioning of the pancreas is thought to be the key to diabetes. Diabetic pancreas may not produce enough insulin, a hormone that is essential to the utilization of carbohydrates as a food by the human body. Under certain circumstances, diabetes may develop even the pancreas produces normal amounts of insulin. In these cases there is apparently a relative deficiency of insulin.

Because the body unable to utilize sugar as a source of energy, it then draws upon protein and fat as energy sources. This results in a gradual wasting away of muscular tissue, which becomes evident as a loss of weight. The use of fats for fuel is potentially even more dangerous. For these are broken down into substances called ketone bodies, which upset the acidity-alkalinity balance of the body.

The result is a condition called acidosis, which may terminate in a coma. This coma is characterized by a fruity aroma of the breath, which is produced by the presence of acetone, one of the ketone bodies. Diabetic coma is distinct from the shock which develops when the patient takes too much insulin. Too much sugar enters the cells too quickly, resulting in a serious shortage of glucose in the blood.

The Symptoms

Diabetic may appear well and completely unaware of his condition until a routine examination of his blood and urine reveals an abnormally high concentration of sugar. The condition progresses until symptoms appear. These include: excessive urination, thirst, dryness of the mouth, weakness, loss of weight, and itching of the genital areas. Less frequent symptoms are excessive hunger and disturbances in vision.

Diabetics are susceptible to cataracts, arteriosclerosis (hardening of the arteries), and heart disease. In diabetics of long standing the kidneys and nervous system may be affected and blindness may be produced by hemorrhages in the eyes. Diabetics must maintain scrupulous care of their feet, avoiding ill-fitting shoes, harsh chemicals, and home surgery.

Diet is an essential aspect of treatment. It should be well-balanced, provide enough calories to maintain ideal weight, and restrict carbohydrates. Many older patients can be controlled on diet alone. Others require insulin or drugs to lower blood sugar. Caution must be observed to avoid insulin shock which may result from too little food, as well as too much insulin. With proper care and attention, diabetics can lead normal lives.

Source : Encyclopedia International by Irving Solomon, M.D.

Tomato Rich Diets Against Diabetes CVD and Cancer

Red Tomato

Tomato (Solanum lycopersicum Linn.) is considered as a vegetable, rather than its botanically as a form of fruit, due to it is mostly used as an ingredient for culinary purposes. Tomato, which in Bahasa Indonesia is known as tomat, has other binomial synonyms, such as, Lycopersicon lycopersicum (L.) H. Karst., and Lycopersicon esculentum Mill.

When I ate tomato as a dessert, first I sliced a tomato into four pieces, put them in a glass, added with few sugar, crushed and mixed the tomato with spoon, and enjoyed it. Thats how I used to enjoy eating tomato, besides of having it as a fruit juice.

There are many health benefits of tomato, including the protection from tumors at various anatomy have been attributed to tomato. According to several scientific studies, tomato is believed to possess antioxidant, anti-inflammatory, anti-metastatic, antimutagenic, anti-diabetic, anti-cancer, anticarcinogenic, cardioprotective, and anti-neurodegenerative effects.

Anti-diabetic Effects

Tomatoes are a rich source of lycopene, β-carotene, α-tomatine, tomatidine, potassium, vitamin C, flavonoids, folate and vitamin E. Among tomato carotenoids, lycopene is the most active antioxidant. Lycopene acts as an antidiabetic agent through lowering the free radical, effectively at the dose of 90 mg/kg body weight, in a study using streptozotocin induced hyperglycaemic rats. (Ali MM, et al. 2009)

In a quasi experimental study, 32 type 2 diabetic patients received 200 g raw tomato daily for eight weeks. The study concluded that daily consumption of 200 g raw tomato, may decrease in systolic and diastolic blood pressure, in which will be useful for reducing cardiovascular risk associated with type 2 diabetes mellitus. (Shidfar F, et al. 2011)

Cardioprotective Effects

Cardiovascular disease (CVD) is the leading cause of human morbidity and mortality in developed countries. Increasing the consumption of fruits and vegetables is recommended for CVD prevention. But, until now, many scientific studies mostly failed to show the effect of consumption of tomato in decreasing the risk of CVD. However, the antioxidant as well as the anti-inflammatory effects of lycopene, could be the background for cardioprotective effects of tomato, or tomato products.

In a study among 39,876 middle aged and older women initially free of CVD and cancer. Dietary intake of lycopene was not strongly associated with the risk of CVD. However, the higher consumption levels of tomato based products, such as, tomato sauce and pizza, had potential reductions in CVD risk, and give cardiovascular benefits. (Sesso HD, et al. 2003)

Lycopene inhibits lymphocyte (a type of white blood cell that is important in the formation of antibodies) proliferation (the growth and reproduction of similar cells) through mechanisms dependent on early cell activation, providing one possible mechanism to explain the beneficial effects of tomato rich diets against CVD. (Mills LM, et al. 2012)

Anti-cancer Effects

Based on several observational studies, the benefit of tomato was strongest for prostate, lung, and stomach cancers. And were also suggested to treat pancreas, colon, rectum, esophagus, oral cavity, breast, and cervix cancers. However, multiple components derived from tomato may contribute to its anti-cancer properties, and higher consumption of tomato or any tomato based products is associated in lowering the risk of cancer.

The high α-tomatine from green tomato extracts strongly inhibited several human cancer cell lines, such as, breast, colon, gastric, and hepatoma. α-Tomatine was found to be highly effective in inhibiting the growth of all human cancer cell lines. (Friedman M, et al. 2009)

Recent study had found that tomatidine, an aglycone of glycoalkaloid tomatine in tomato, possessed anti-inflammatory properties and may serve as a chemosensitizer in multidrug-resistant tumor cells. Just like embelin in my previous post about vidanga, tomatidine significantly decreased the nuclear level of nuclear factor kappa B (NF-κB).

NF-κB is a transcription factor which regulates several genes associated with inflammation, proliferation, carcinogenesis, and apoptosis. The study also suggested that tomatidine may potentially use in anti-metastatic therapy, as a new therapeutic agent. (Yan KH, et al. 2013)

So, whatever the variety of tomatoes around the world, all them have huge benefits for us. And tomato based products may also contribute to our health. Stay healthy! Let us not waste our health to look for treasure (wealth) and then squandered our treasure to seek health!

Exercise and Type 2 Diabetes

One of the most undemanding and the most workable ways to knock over blood sugar amount, eliminate the dangers of “cardiovascular disease,” and perk up health and welfare in general is exercise.

In spite of that, in today’s inactive world where almost every indispensable job can be carried out online, from the ergonomic chair in front of a computer, or with a streaming line of messages from a fax machine, exercising can be a hard argument to win over.

The Weight of Exercise

Everyone should exercise, yet the health experts tells us that only 30% of the United States population gets the recommended thirty minutes of daily physical activity, and 25% are not active at all. In fact, inactivity is thought to be one of the key reasons for the surge of type 2 diabetes in the U.S., because inactivity and obesity promote insulin resistance.

The good news is that it is never too late to get moving, and exercise is one of the easiest ways to start controlling your diabetes. For people with type 2 diabetes in particular, exercise can improve insulin sensitivity, lower the risk of heart disease, and promote weight loss.

Type 2 Diabetes

Diabetes is on the rise. The number of people diagnosed with diabetes every year increased by 48% between 1980 and 1994. Nearly all the new cases are Type 2 Diabetes, or adult-onset, the kind that moves in around middle age. Symptoms of Type 2 Diabetes include increased thirst, appetite, and need to urinate; feeling tired, edgy, or sick to the stomach; blurred vision; tingling or loss of feeling in the hands.

The causes of type 2 diabetes are complex and not completely understood, although research is uncovering new clues at a rapid pace.

However, it has already been proven that one of the reasons for the boom in type 2 diabetes is the widening of waistbands and the trend toward a more deskbound and inactive lifestyle in the United States and other developed countries. In America, the shift has been striking; in the 1990s alone, obesity increased by 61% and diagnosed diabetes by 49%.

For this reason, health experts encourage those who already have type 2 diabetes to start employing the wonders that exercise can do for them. Without exercise, people have the tendency to become obese. Once they are obese, they have bigger chances of accumulating type 2 diabetes.

Today, the U.S. Department of Health and Human Services reports that over 80% of people with type 2 diabetes are clinically overweight. Therefore, it is high time that people, whether inflicted with type 2 diabetes or not, should start doing those jumping and stretching activities.

Getting Started

The first order of business with any exercise plan, especially if you are a “dyed-in-the-wool” sluggish, is to consult with your health care provider. If you have cardiac risk factors, the health care provider may want to perform a stress test to establish a safe level of exercise for you.

Certain diabetic complications will also dictate what type of exercise program you can take on. Activities like weightlifting, jogging, or high-impact aerobics can possibly pose a risk for people with diabetic retinopathy due to the risk for further blood vessel damage and possible retinal detachment.

If you are already active in sports or work out regularly, it will still benefit you to discuss your regular routine with your doctor. If you are taking insulin, you may need to take special precautions to prevent hypoglycemia during your workout.

Start Slow

For those who have type 2 diabetes, your exercise routine can be as simple as a brisk nightly neighborhood walk. If you have not been very active before now, start slowly and work your way up. Walk the dog or get out in the yard and rake. Take the stairs instead of the elevator. Park in the back of the lot and walk. Every little bit does work, in fact, it really helps a lot.

As little as 15 to 30 minutes of daily, heart-pumping exercise can make a big difference in your blood glucose control and your risk of developing diabetic complications. One of the easiest and least expensive ways of getting moving is to start a walking program. All you need is a good pair of well-fitting, supportive shoes and a direction to head in.

Indeed, you do not have to waste too many expenses on costly “health club memberships,” or the most up-to-date health device to start pumping those fats out. What you need is the willingness and the determination to start exercising to a healthier, type 2 diabetes-free life.

The results would be the sweetest rewards from the effort that you have exerted.